The absolute pinnacle of medical ninjutsu, created by the greatest of medical ninja, Tsunade, it is the ultimate regeneration technique. By releasing the great volume of chakra stored in her forehead at once, the body's cell division is forcibly stimulated by proteins, reconstructing all organs and all tissues making up the human body. The technique itself does not regenerate the old cells, rather it hastens the creation of new ones through division. If this technique is used, a body whose vital organs are so gravely injured that it cannot bear it any longer will be instantly restored to its uninjured state. By Tsunade's own claim, as long as she has chakra it is impossible for her to die by any means, as such she gains a form of "immortality" throughout the duration of the technique.
However, a body's cells can only split a certain number of times in a lifetime, and by speeding up this process, users of this technique are basically shortening their natural lifespan.
- According to the second databook, Creation Rebirth was developed by Tsunade for the sake of continuing to protect the lives of her comrades. That is the resolution hidden in this technique.